Colorado vs. USC: Odds, Spread, Line, and Picks for the 2023 College Football Matchup

Colorado vs. USC

The Colorado Buffaloes will host the USC Trojans on Saturday, September 30, 2023, in a highly anticipated Pac-12 matchup. The Trojans are the clear favorites to win the game, but the Buffaloes are looking to make a statement under their new head coach, Deion Sanders.

Odds, Spread, and Line

the odds, spread, and line for the Colorado vs. USC game

Here are the odds, spread, and line for the Colorado vs. USC game:

  • Moneyline: USC -1527, Colorado +841
  • Spread: USC -21.5
  • Over/Under: 73 points


USC is 4-0 on the season, while Colorado is 3-1. The Trojans are 2-2 against the spread, while the Buffaloes are also 2-2. USC is 3-1 over the under, while Colorado is 2-2.

Deion Sanders Predictions

Sanders has said that he believes his team can beat USC, but that they will need to play a perfect game. He has also said that he is excited about the matchup, and that he believes his team is ready to make a statement.

Proven Model Predictions

A proven college football model predicts that USC will win the game by a score of 42-21. The model also predicts that the total points scored will be under 73.


Based on the odds, trends, and predictions, here are our picks for the Colorado vs. USC game:

  • Pick: USC -21.5
  • Pick: Under 73 points

Why Pick USC?

Why Pick USC?

USC is the better team on paper. They have more talent, more experience, and more confidence. The Trojans are also coming off a bye week, while the Buffaloes are coming off a tough loss to Oregon.

Why Pick the Under?

Both teams have good defenses. USC ranks 10th in the nation in scoring defense, while Colorado ranks 25th. Both teams have also struggled to score points consistently this season. The weather conditions in Boulder are expected to be windy and cold, which could make it difficult to score points.


USC is the favorite to win the game, and they should be able to cover the spread. The total points scored is likely to be under 73. However, the Buffaloes are a dangerous team, and they should not be overlooked.

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